5 Natural Ways to Support GLP 1 in PCOS

Not everyone with PCOS wants to take medication. GLP-1 receptor agonists such as semaglutide (Wegovy, Ozempic) and liraglutide (Saxenda) may help with weight loss and insulin resistance, but they are not the only way to influence the GLP-1 pathway.

The body naturally produces GLP-1 in response to food and gut signalling. This hormone helps regulate blood sugar, slow gastric emptying, and promote satiety – all functions that are sometimes disrupted in PCOS. So, it makes sense to explore how nutrition and lifestyle can enhance your body’s own GLP-1 production and responsiveness.

Here are five evidence-based strategies that may support GLP-1 naturally, and benefit PCOS symptoms in the process:

1. Include foods rich in soluble fibre

Soluble fibre slows digestion, helps to balance blood glucose, and supports your gut microbiome – which all in turn can help to enhance GLP-1 secretion. Soluble fibre also plays a role in improving insulin sensitivity and reducing circulating androgens (male hormones, like testosterone).

Good sources include oats, ground flaxseed, chia seeds, cooked apples and pears (with the skin), beans, lentils, avocado and carrots. Aim to include 10g soluble fibre food in your diet every day.

2. Don’t overlook eggs

Research shows that eggs are a source of bioactive peptides that appear to stimulate GLP-1 secretion. In a randomised crossover study, participants who ate eggs for breakfast had significantly higher GLP-1 levels post-meal compared to those who consumed cereal or a croissant-based meal.

Eggs also provide high-quality protein, choline and B vitamins – all of which support hormone balance, liver detoxification, and brain function.

If you don’t eat eggs, other protein sources like tofu, tempeh, fish and legumes may offer similar benefits, although their GLP-1 response has been less studied.

3. Try intermittent fasting – cautiously and mindfully

Time-restricted eating (such as a 10- or 12-hour eating window) may enhance GLP-1 sensitivity and improve insulin signalling. Several small studies suggest that intermittent fasting protocols can lead to increased GLP-1 levels and improved glycaemic control.

However, fasting isn’t suitable for everyone. In women with PCOS who are underweight, have disordered eating patterns, or experience blood sugar crashes, fasting may do more harm than good. It should be approached carefully and always personalised.

4. Incorporate bitter foods and herbs

Bitter compounds stimulate receptors in the gut and tongue that may increase GLP-1 secretion and slow gastric emptying. This includes foods like rocket, chicory, dandelion greens, grapefruit, endive, and radicchio.

Herbal bitters such as gentian and artichoke extract are also under investigation for their potential effects on satiety and post-meal glucose control, although more research is needed in women with PCOS specifically.

5. Support the gut microbiome

Short-chain fatty acids (SCFAs), produced by the fermentation of dietary fibre by gut bacteria, have been shown to stimulate GLP-1 release via interaction with intestinal receptors. A healthy and diverse microbiome may therefore play a central role in regulating GLP-1 naturally.

To support this, include a variety of prebiotic-rich foods (onion, garlic, leeks, asparagus, oats, flaxseed), fermented foods (sauerkraut, kefir, yoghurt, miso), and polyphenol-rich foods such as berries and green tea.

For women with PCOS who prefer a natural or food-first approach, there are several well-researched ways to support GLP-1 signalling without medication. These strategies may help with appetite regulation, insulin sensitivity and hormone balance – particularly when combined with a personalised nutrition plan. If you are interested in finding out more, why not book a free call with us here?

**This article is for general information only and is not intended to diagnose, treat or advise on medical conditions. Always speak to your GP or a qualified health professional before starting supplements or changing your medication. BANT-registered nutrition professionals do not diagnose or treat medical conditions, nor do they recommend, prescribe or alter any medication**

5 Top Nutrition Tips While Taking GLP-1 Agonists for PCOS

GLP-1 receptor agonists – including semaglutide (Wegovy, Ozempic) and liraglutide (Saxenda) – are growing in popularity among women with PCOS, particularly those who are struggling with insulin resistance and weight management. These medications mimic the body’s natural GLP-1 hormone, which helps regulate blood sugar, slow digestion, and reduce appetite.

While these effects can be beneficial, they also raise important questions about nutrition. With significantly reduced appetite, how can you ensure you’re getting enough nutrients to support energy, hormones and long-term health? And are there specific foods that can support how these medications work?

Here are some evidence-based strategies to help you stay well-nourished while taking GLP-1 agonists.

1. Prioritise protein – even if you're eating less

GLP-1 agonists can make it difficult to eat full meals. This can unintentionally lead to low protein intake, especially if you’re snacking or eating very small portions. However, protein is essential for preserving muscle mass, supporting metabolic rate, regulating blood sugar, and aiding hormone production.

Research suggests women with PCOS may benefit from a protein intake of around 1.2–1.6 g per kg of body weight per day. This is higher than the standard RNI, especially during periods of weight loss. If appetite is low, aim to include 20–30g of protein at each meal – even if the meal is small.

Easy protein-rich options include eggs, fish, Greek yoghurt, tofu, tempeh, pulses, lean poultry, and protein powders made from pea or whey.

2. Don’t forget fibre – especially the soluble kind

Soluble fibre supports digestion, blood sugar regulation and appetite control – all crucial for women with PCOS. It’s also known to stimulate the body’s own GLP-1 release, supporting the same pathway as the medications.

Sources include oats, flaxseed, chia seeds, apples, pears, cooked carrots, beans and lentils. If you’re struggling with volume, a tablespoon of ground flaxseed stirred into porridge, yoghurt or a smoothie is an easy way to increase soluble fibre without adding bulk.

Increased fibre intake is associated with improved insulin sensitivity and lower androgens in PCOS. It also supports gut microbiome diversity – an area increasingly linked with hormone regulation and mood.

3. Watch for micronutrient shortfalls

Reduced appetite and slower digestion can increase the risk of missing out on key vitamins and minerals. Early evidence suggests that long-term GLP-1 agonist use may impact the absorption of B12 and fat-soluble vitamins such as A, D, E and K – particularly in those with existing digestive issues.

Common nutrient deficiencies in PCOS include magnesium, vitamin D, iron, folate and B12. If you’re experiencing fatigue, mood changes or digestive discomfort while on medication, speak with your GP or nutritionist about testing or supplement support.

Eating smaller meals that are nutrient-dense – such as a quinoa salad with avocado and salmon, or a smoothie with spinach, berries and protein powder – can help you meet your needs more easily.

4. Hydration matters – especially with slower digestion

GLP-1 agonists slow the emptying of the stomach, which may increase bloating, nausea or constipation for some women. Staying well hydrated can support digestion and reduce discomfort.

Aim for at least 1.5–2 litres of water daily, and consider herbal teas such as ginger, peppermint or fennel to ease digestive symptoms. A small amount of lemon juice or apple cider vinegar before meals may also support stomach acid and enzyme release – although this should be avoided if you have reflux or gastritis.

If constipation becomes a concern, increasing both soluble fibre and fluid together is key. 

5. Build in rest and nourishment – not just weight loss goals

It can be tempting to see rapid weight loss as the main goal while on a GLP-1 agonist. But from a Functional Medicine perspective, weight is only one part of a much bigger picture. Hormone balance, ovulation, stress resilience, gut health and sleep all play critical roles in PCOS outcomes.

Skipping meals, undereating or ignoring hunger signals (even if they’re rare) can leave the body undernourished and stressed – potentially worsening hormone imbalances over time. Wherever possible, choose foods that feel grounding, satisfying and nutrient-rich, even in small amounts.

Slowing down at mealtimes, chewing well and tuning into your body’s cues can also improve digestion and nutrient absorption.

GLP-1 receptor agonists may offer useful support for women with PCOS, particularly where insulin resistance is a key driver. But medications are most effective when paired with thoughtful, individualised nutrition. Prioritising protein, fibre and nutrient density – even in small portions – helps protect your long-term health and hormone balance. If you’re unsure where to start, speak to your GP or feel free to get in touch with us here.

**As always, this article is for educational purposes only and does not replace personalised medical advice. Nutritional therapists do not diagnose or treat medical conditions or recommend medications. If you’re unsure about your nutrition needs while on a GLP-1 agonist, please speak with your GP and a qualified nutritional therapist registered with BANT**

GLP 1 Agonists and PCOS

Weighing Up the Pros and Cons

GLP-1 receptor agonists – such as semaglutide (Ozempic, Wegovy) or liraglutide (Saxenda) – are gaining attention for their effects on weight loss, blood sugar regulation, and insulin resistance. All of these are key issues in PCOS, but these medications were never designed specifically for PCOS. So, how relevant are they, and what does the research say about their benefits and risks to those of us with PCOS?

What are GLP-1 receptor agonists?

GLP-1 (glucagon-like peptide-1) is a hormone naturally produced in the gut, released in response to food, and it plays several important roles - regulating blood sugar, insulin release, appetite and digestion. GLP-1 receptor agonists are medications that mimic the action of this hormone. They were originally developed for type 2 diabetes but are now increasingly prescribed off-label for weight loss and insulin resistance.

GLP-1 agonists work by helping to lower blood glucose by increasing insulin secretion and decreasing glucagon (a hormone that raises blood sugar). They also slow gastric emptying and promote a feeling of fullness, which can lead to reduced food intake and weight loss.

Why are they being used for PCOS?

Some women with PCOS experience insulin resistance, difficulty with weight loss, and increased appetite. There’s a growing body of research suggesting that GLP-1 receptor agonists may improve metabolic, hormonal, and reproductive parameters in PCOS.

Potential benefits:

• Weight loss – especially in those living with obesity or severe insulin resistance
• Improved insulin sensitivity and lower fasting insulin - especially in those with severe insulin resistance
• Reduced appetite 

Potential drawbacks:

• Side effects: nausea, constipation, vomiting, gallbladder issues, and fatigue are commonly reported
• Nutrient deficiencies: reduced appetite can lead to low intake of protein, iron, B12, and fibre
• Loss of muscle mass: rapid weight loss may lead to a decline in lean mass if not well supported
• Cost and access: these medications are not always available on the NHS for PCOS and can be expensive privately
• Unknown long-term effects: most studies in PCOS are under 1 year, and there is no data yet on long-term safety or fertility outcomes

Things to consider

GLP-1 agonists are not a quick fix – they should be paired with dietary and lifestyle strategies to avoid potential nutritional deficiencies or any potential rebound weight gain when stopping the medication. Appetite suppression can also make it hard to eat enough protein or vegetables, which are key for ongoing health.

Also, they are not suitable for everyone. People with a history of pancreatitis, certain thyroid conditions, or gallbladder disease should avoid them. And they should never be used during pregnancy or while trying to conceive.

The research shows that GLP-1 agonists may offer real benefits to some women with PCOS – particularly those who have struggled with insulin resistance and weight for a long time – but they are not without risk. They don’t replace the foundations of hormone support: blood sugar balance, stress regulation, nutrient-dense meals, and regular movement.

If you’re considering medication, it’s important to speak with your GP or endocrinologist. If you’re interested in supporting your body’s own production of GLP-1, check out my blog here.

**This article is for educational purposes only and is not a substitute for medical advice. BANT-registered nutrition practitioners do not diagnose or treat medical conditions, nor do they prescribe or alter medication. Always consult your GP before making any changes to your medications or supplements**
 

Eat your way to amazing skin

Most people don’t give a second’s thought to their skin – unless they’re scowling at the wrinkles or wobbly bits in the mirror. But when you suffer with PCOS, it can be something that you think about all the time. Sometimes making us avoid reflective surfaces or feel we can’t go out without a ton of make-up.

While diet isn’t the only answer, there are some changes that we can make fairly easily, that can have hugely positive effects on our skin.

Ditch the bad guys

A diet high in refined carbohydrates and sugar can not only play havoc with our hormones, but with PCOS can cause insulin to spike consistently leading to high levels of androgens (male hormones). Stick to a wholefoods diet full of good quality protein, brightly coloured veggies and healthy fats.

Alcohol, caffeine, food additives like flavourings and colourings, salt, sugar, and tobacco are full of cell-damaging free radicals, which play havoc with your skin. Ideally, cut them out altogether but certainly reduce them as much as you can.  

Be fat-friendly

Essential fats found in fish, avocados, nuts and seeds keep cell membranes soft and smooth – they’re nature’s perfect skin plumpers. Just in case the word ‘fat’ sends a red flag up for you, I want to reassure you that scientists have finally admitted all that ‘fat is bad for you and makes you fat’ propaganda was utterly flawed. Eating the right fat is not only not bad, but also really, truly GOOD for your health. And, when inflammation is such a key part of why our PCOS symptoms happen, particularly cystic acne, including those gorgeous anti-inflammatory Omega 3 fats in oily fish, nuts and seeds can really help.

Eat to reduce inflammation

Stock up on antioxidant-rich fruit and veg. These are crucial for your entire body – not just your skin. They help to reduce the systemic inflammation linked with PCOS. Eat them raw or lightly steamed as cooking for long periods destroys enzymes, minerals and vitamins and can create skin-damaging free radicals. 

A couple of simple exercises are these: make a concerted effort to add at least one extra portion of veg every night this week to your evening meal. You should also aim to ‘eat a rainbow’ over the course of the week – that means picking as many different colours of fruit and veg as you can. 

As a very general rule, each different colour group contains a different set of plant chemicals. Scientists now know that bringing a variety of different antioxidants into your diet has a synergistic effect, which means the combined result is more powerful than the individual parts. 

Drink up!

Keep skin cells plump and full by watching your hydration, this can help prevent overproduction of sebum, if you are well hydrated. Cells also need water to rebuild and to remove the build-up of waste products (toxins). It’s a very simple (and free) step that most people don’t prioritise and yet the results and be striking. Aim for at least 2-3 litres a day depending on weather conditions and your level of exercise. You’ll soon see the benefit for your skin. 

Helpful nutrients for skin health

Vitamin A helps control the rate of keratin. A lack of vitamin A can result in dry, rough skin. Foods to include: sweet potato, carrots, butternut squash, spinach, kale, collard greens, turnip greens, romaine lettuce.

Zinc for the production of skin cells. It also helps to reduce androgen activity, and it has anti-bacterial and anti-inflammatory properties. Foods to include: venison, fish, ginger root, lamb, lean beef, turkey, green vegetables, oats, nuts, sesame seeds, pumpkin seeds, yoghurt, scallops.

Vitamins A, C, E and selenium are antioxidants that limit the damage by free radicals and helps the skin to heal. Foods to include (aside from the vitamin C foods, above, and the vitamin A foods, below): sunflower seeds, almonds, spinach, swiss chard, papaya, mustard greens, asparagus, peppers, Brazil nuts, fresh tuna, some meats including pork, beef, turkey and chicken, cottage cheese, eggs, brown rice, sunflower seeds, spinach, oats, mushrooms.

Essential fats for making cell membranes. A lack of essential fats causes cells to dry out too quickly, resulting in dry skin. Foods to include: oily fish (salmon, sardines, halibut, scallops), flaxseed, walnuts, soya beans, tofu.

Watch what you put on your body, too

The skin is the largest organ in the body with a surface area about the size of a double bed. It soaks everything up you put on it, and what soaks in ends up in your blood stream. 

So, if your shampoo and conditioner or shower gel (all of which wash over you as you shower), or your body lotions or creams contain nasty chemicals like parabens or sodium lauryl/laureth sulplate, you are feeding yourself synthetic oestrogens that can wreak havoc with your hormones. Check labels for ingredients – often they may be marked as paraben-free. 

Learn how to deal with problem skin

A targeted nutrition plan can work wonders for skin problems like acne, particularly with PCOS. This kind of personalised nutrition is often poorly understood and isn’t really talked about in the media. It doesn’t work to just add to your diet a single ‘superfood’. However, a bespoke plan that takes into all of your skin – and health – concerns can make a huge difference. Ask me how. We’d love to help – why not book a call?

Foods for a Healthy Gut

Some foods are excellent for supporting our digestion and here are some of my favourites that I suggest to clients on a regular basis:

Cruciferous vegetables

These fab veg bring amazing health benefits on a number of different levels. Since we’re talking about foods that are helpful for your digestion, you should know that they contain compounds called glucosinolates, which are fermented by bacteria and used as fuel. They are prebiotic.

Examples include: Bok choy, broccoli, Brussels sprouts, cabbage, cauliflower, kale , rocket, spring greens, watercress.

Fermented foods

Fermented foods have a long tradition in some parts of the world, especially Asia, Africa, and Eastern Europe. Bacteria (and sometimes beneficial yeasts) might be involved in the process and the result is an increase of good bacteria in the foods. You’ve probably heard of live or ‘bio’ yoghurt.

Some of these other probiotic foods might sound peculiar and a little ‘advanced’ for most regular people. However, they are now commonly found on supermarket shelves and, while they might not be the kind of product you would usually go for, it is always worth experimenting. Kimchi, in particular, is often combined with chilli and other flavours and is far tastier than its name might suggest.

Examples include yoghurt, pickles (gherkins), sauerkraut, kimchi (fermented cabbage), tempeh (fermented soya beans), natto (fermented soya beans), miso soup (fermented soya beans), tamari soy sauce, buttermilk, some cheeses like cottage cheese, gouda, mozzarella and cheddar.

Fermented drinks

Like other fermented products, these were once only found in health food shops and were perhaps the prevail of people who ate a very clean and unprocessed diet. 

These were a secret waiting for the masses to discover. Often flavoured with fruits, they really are delicious and do not taste 'worthy'. You'll find them in the chilled drinks section in most supermarkets.

Kombucha (fermented tea - sweet and fizzy but without sugar) and kefir (fermented dairy drink very much like a yoghurt drink) are examples.

The only way you’ll know if it’s for you is to try!

Fibre

Fibre is one of the best things to eat to support healthy digestion. Fibre is described as being either insoluble or soluble.

This is part of the plant wall in fruit and veg. It’s indigestible so it passes right through your system, sweeping up toxins and other waste products as it goes, and keeping you regular. The undigested fibre is also fermented by gut bacteria, producing the beneficial short chain fatty acids mentioned earlier.

YOU CAN FIND INSOLUBLE FIBRE IN:

Fruit and veg, beans and lentils, oats and wholegrain foods like brown rice and wheat.

This can be partially digested and is well-celebrated for its ability to reduce cholesterol in the blood and normalise blood sugar levels.

YOU CAN FIND SOLUBLE FIBRE IN:

Oats, veg, fruit (especially apples, pears, berries, and citrus fruits), beans and lentils.

Anti-Microbial Foods

Some foods exert a natural antibiotic or anti-fungal effect and can be useful for keeping nasties like pathogenic bacteria or unwelcome yeasts at bay.

These include caprylic acid found in coconut. Coconut oil is also a very good oil to use in cooking, especially at high temperatures.

Garlic contains the active ingredient allicin, which has historically proven itself to be an effective killer of both bacteria and viruses, making it a great immune-boosting ingredient. Use it raw wherever possible.

Olive oil – the oleic acid has anti-bacterial properties. Use it generously to dress salads and veg.

And we can’t have a list of the foods to add in, without looking at what we need to avoid for a happy tummy:

Sugar and refined carbohydrates

In same way there are things your digestive system loves, there are things it will not love you for. Sugar. That’s the number one thing to avoid, plus anything that contains added sugar.

Other things your tummy is not fond of include highly refined products like white rice, pasta, pastry and snacks like crisps and biscuits.

If you would like to take a look at your gut health – whether you have symptoms or would just like to be optimally well – why not book in a free call? You can book via the link.

Understanding Endometriosis vs. PCOS

It is Endometriosis Awareness Month this month. Endometriosis affects about 1.5 million women in the UK, but it remains one of the most under-diagnosed conditions. 

While we are PCOS specialists here at PCOS Clinics, we often see women with endometriosis as well as PCOS in clinic. So, what’s the difference?

Endometriosis and polycystic ovary syndrome (PCOS) are two common conditions that affect women. While both conditions can cause menstrual irregularities and fertility challenges, they differ in their underlying hormonal imbalances, symptoms, and treatment approaches. Understanding these differences is key to seeking the right diagnosis and treatment.

Endometriosis vs. PCOS: How They Differ

Both conditions can lead to heavy menstrual bleeding and issues with fertility, but they have distinct causes and symptoms:

• Endometriosis is linked to high levels of oestrogen, leading to the growth of uterine-like tissue outside the uterus.
• PCOS is caused by an overproduction of androgens (male hormones), leading to ovarian cysts, irregular periods, and other metabolic effects.
• It is possible to have both conditions simultaneously, complicating diagnosis and treatment.

Symptoms of Endometriosis vs. PCOS

Prevalence of Endometriosis and PCOS

• Endometriosis affects approximately 10–15% of women and up to 70% of those experiencing chronic pelvic pain.
• PCOS is more common, affecting 5–20% of women of reproductive age, with around 80% of ovulation-related infertility cases linked to PCOS.

What Causes Endometriosis and PCOS?

Endometriosis Causes

While the exact causes are not yet known, the following hypotheses have been put forward:

• Retrograde menstruation: Uterine tissue moves into the pelvic cavity instead of exiting the body.
• Immune system dysfunction: The immune system fails to eliminate misplaced endometrial cells
• Cell transformation: Some cells outside the uterus may transform into endometrial-like cells.
• Post-surgery implantation: Uterine cells may spread after surgeries like a hysterectomy or C-section.

PCOS Causes

• Genes: PCOS is a genetic condition
• Hormonal imbalance: High levels of testosterone and other androgens affect ovarian function
• Insulin resistance: High levels of insulin use can increase androgen production.
• Inflammation: Chronic inflammation contributes to excessive androgen levels.
• Stress: high levels of stress hormones can contribute to excessive androgen production.

Who is at Risk?

Risk Factors for Endometriosis

• Family history of endometriosis
• Early menstruation (before 11 years old)
• Short menstrual cycles (<27 days)
• Heavy, prolonged periods (>7 days)
• Infertility

Risk Factors for PCOS

• Family history of PCOS
• Insulin resistance or diabetes
• High levels of stress
• High levels of inflammation

Can You Have Both Conditions?

Yes. Studies suggest a strong link between PCOS and endometriosis, particularly in individuals experiencing pelvic pain or infertility. 

High androgen and insulin levels in PCOS may contribute to anovulatory periods (periods where we don’t ovulate), which may lead to higher levels of oestrogen, potentially exacerbating endometriosis.

Conventional Treatment Options for Endometriosis and PCOS

Endometriosis Treatment

• Hormonal therapy: Birth control or hormonal treatments to lower oestrogen levels
• Pain management: Over-the-counter pain relievers
• Surgery: Removal of endometrial tissue or, in severe cases, a hysterectomy
• Lifestyle changes: A balanced diet and exercise to help manage symptoms

PCOS Treatment

• Hormonal therapy: Birth control to regulate hormones
• Fertility treatments: Ovulation-inducing medication for those trying to conceive
• Diabetes medication: Helps manage insulin resistance
• Acne and hair treatments: Medications to manage excess hair growth and acne
• Lifestyle changes: A balanced diet and exercise to help manage symptoms

When to See a Doctor

Seek medical advice if you experience:

• Pelvic pain or abnormal menstrual bleeding
• Pain during or after intercourse
• Irregular or absent periods
• Difficulty conceiving
• Signs of excess androgen (e.g., excess hair growth, acne, hair loss)

Early diagnosis is crucial for symptom management. A gynaecologist or endocrinologist can provide a tailored treatment plan.

Final Thoughts

Endometriosis and PCOS are distinct but often misunderstood conditions that can significantly impact overall health. 

While endometriosis results from excessive oestrogen and misplaced uterine tissue growth, PCOS stems from an overproduction of androgens, leading to metabolic and reproductive complications. If you suspect you have either condition, early medical intervention can help manage symptoms and improve quality of life. And don’t forget the power of diet and lifestyle changes – if you’d like to know more, get in touch.